It took ten doctors and a year to discover the root cause: We’d been bitten by unseen ticks harboring the parasites that cause Lyme disease and babesiosis, a malaria-like disease. This process entails acquiring “libraries” of thousands of known chemical compounds and drugs, then mixing Lyme bacteria with each in tiny wells to see which ones are best at killing the organisms. Our road to recovery was grueling, requiring five years of intermittent antimicrobial treatments. Posted 10/7/2019 7:39 AM (GMT -7) Azlocillin sodium is another drug to watch as just like Disulfiram it completely sterilized Borrelia in vitro in that Stanford study. The study suggests it could also be effective for treating patients infected with drug-tolerant bacteria that may cause lingering symptoms. One, for instance, is used to treat alcohol abuse disorder. There may be as many as 30 distinct pathogenic species of Bartonella-like organisms, most of which have never been clinically defined. Image courtesy of Michal Tal, PhD, instructor at Stanford’s Institute for Stem Cell Biology and Regenerative Medicine. Editor’s note: Any medical information included is based on a personal experience. They treated the mice at different stages of the disease and gave them a daily dose of either azlocillin, cefotaxime, or the standard treatment for Lyme disease for 5 days. This could lead to a significant decrease in the need for extended treatment for Lyme disease. Dr. Elizabeth Maloney reviews the uncertain science on treatment options for high-risk tick bites and Lyme rashes. Early results of this team’s screening process, first published in 2016, led to the discovery of another promising Lyme drug candidate, disulfiram, which is approved by the Food and Drug Administration for the treatment of alcohol abuse disorder. Azlocillin was previously approved by the FDA for the treatment of alcohol abuse disorder. Researchers plan to conduct a clinical trial. This drug study, published online in Scientific Reports, was conducted by a team led by Jayakumar Rajadas, PhD, assistant professor of medicine and director of Stanford’s Biomaterials and Advanced Drug Delivery Laboratory, and research associate Venkata Raveendra Pothineni, PhD. After the threat has passed, the bacteria can reemerge to cause active disease. Photo by Gabor Tinz/Shutterstock. “We have been screening potential drugs for six years,” Pothineni said. Questions? A new Stanford Medicine study in lab dishes and mice provides evidence that the drug azlocillin completely kills off the disease-causing bacteria Borrelia burgdorferi at the onset of the illness. In this most recent study, azlocillin, one of the top-20 contenders, was shown to eclipse a total of 7,450 compounds because it is more effective in killing B. burgdorferi and causes fewer side effects. For questions or concerns regarding health, please consult a doctor or medical professional. The Healing Power of “Realistic, Practical Hope”. For those people, the antibiotics don’t work, and symptoms of fatigue, cognitive impairment, and muscle pain may linger for years, and in some cases, indefinite. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease … Along the way, I’ve met many people suffering with this horrible, lingering disease. Veteran Member. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease Control and Prevention. Putting Lyme Behind You: Basic Lyme for Patients, Family and Friends, Lyme Disease and MSIDS: Diagnosis and Treatment Protocols for the Chronically Ill Patient, Review of Lyme disease Diagnosis and Treatment, Using Integrative Medicine to Heal from Lyme Disease. Article reprinted with permission from Stanford’s Institute for Stem Cell Biology and Regenerative Medicine: Can Treating Mast Cells Help Neurological Lyme Disease? “Some researchers think this may be due to drug-tolerant bacteria living in the body and continuing to cause disease,” said Rajadas, who is also a member of the Lyme Disease Working Group at Stanford. Photo by Gabor Tinz/Shutterstock. The most effective and safest molecules were tested in animal models. Comments? We have tested 50 molecules in the dish. SOURCE OF PRESS RELEASE: Stanford Medicine News Center. Is it possible that there may finally be a drug that might successfully treat Chronic Lyme Disease? Azlocillin also appears to kill drug-tolerant persisters very effectively. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease. A study provides evidence that the drug azlocillin eliminates the bacteria that cause Lyme disease at the onset of infection in lab mice and cultures. Lyme disease affects more than 300,000 people annually, according to the Centers for Disease Control and Prevention. Image courtesy of Michal Tal, PhD, instructor at Stanford’s Institute for Stem Cell Biology and Regenerative Medicine. Common persistent Lyme symptoms include fatigue, joint pain, muscle pain, numbness, tingling, burning pains, and changes in mood, memory or mental clarity. Article reprinted with permission from Stanford’s Institute for Stem Cell Biology and Regenerative Medicine: https://scopeblog.stanford.edu/2020/03/30/lyme-disease-bacteria-eradicated-by-new-drug-in-early-tests/.